Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes
Wound Treatments Abstract Environmental factors may alter the fetal genome to cause metabolic diseases.It is unknown whether embryonic immune cell programming impacts the risk of type 2 diabetes in later life.We demonstrate that transplantation of fetal hematopoietic stem cells (HSCs) made vitamin D deficient in utero induce diabetes in vitamin D-s